Ontology highlight
ABSTRACT:
SUBMITTER: Wang LX
PROVIDER: S-EPMC3116644 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Wang Li-Xin LX Li Yuhuan Y Yang Guojun G Pang Pui-yi PY Haley Dan D Walker Edwin B EB Urba Walter J WJ Hu Hong-Ming HM
European journal of immunology 20100501 5
Lymphodeleption prior to adoptive transfer of tumor-specific T cells greatly improves the clinical efficacy of adoptive T-cell therapy for patients with advanced melanoma, and increases the therapeutic efficacy of cancer vaccines in animal models. Lymphodepletion reduces competition between lymphocytes, and thus creates "space" for enhanced expansion and survival of tumor-specific T cells. Within the lymphodepleted host, Ag-specific T cells still need to compete with other lymphocytes that under ...[more]