Dataset Information

Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.

ABSTRACT: Over 90% of people activate the left hemisphere more than the right hemisphere for language processing. Here, we show that the degree to which language is left lateralized is inversely related to the degree to which left frontal regions drive activity in homotopic right frontal regions. Lateralization was assessed in 60 subjects using functional magnetic resonance imaging (fMRI) activation for semantic decisions on verbal (written words) and nonverbal (pictures of objects) stimuli. Regional interactions between left and right ventral and dorsal frontal regions were assessed using dynamic causal modeling (DCM), random-effects Bayesian model selection at the family level, and Bayesian model averaging at the connection level. We found that 1) semantic decisions on words and pictures modulated interhemispheric coupling between the left and right dorsal frontal regions, 2) activation was more left lateralized for words than pictures, and 3) for words only, left lateralization was greater when the coupling from the left to right dorsal frontal cortex was reduced. These results have theoretical implications for understanding how left and right hemispheres communicate with one another during the processing of lateralized functions.

SUBMITTER: Seghier ML

PROVIDER: S-EPMC3116735 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.

Seghier Mohamed L ML Josse Goulven G Leff Alexander P AP Price Cathy J CJ

Cerebral cortex (New York, N.Y. : 1991) 20101125 7

Over 90% of people activate the left hemisphere more than the right hemisphere for language processing. Here, we show that the degree to which language is left lateralized is inversely related to the degree to which left frontal regions drive activity in homotopic right frontal regions. Lateralization was assessed in 60 subjects using functional magnetic resonance imaging (fMRI) activation for semantic decisions on verbal (written words) and nonverbal (pictures of objects) stimuli. Regional inte ...[more]

PMID: 21109578

Similar Datasets

Project description:Two variants of semantic dementia are recognized based on the laterality of temporal lobe involvement: a left-predominant variant associated with verbal knowledge impairment and a right-predominant variant associated with behavioural changes and non-verbal knowledge loss. This cross-sectional clinicoradiologic study aimed to assess whole hippocampal, subregion, and/or subfield volume loss in semantic dementia versus controls and across its variants. Thirty-five semantic dementia participants and 15 controls from the Neurodegenerative Research Group at Mayo Clinic who had completed 3.0-T volumetric magnetic resonance imaging and 18F-fluorodeoxyglucose-positron emission tomography were included. Classification as left-predominant (n = 25) or right-predominant (n = 10) variant was based on temporal lobe hypometabolism. Volumes of hippocampal subregions (head, body, and tail) and subfields (parasubiculum, presubiculum, subiculum, cornu ammonis 1, cornu ammonis 3, cornu ammonis 4, dentate gyrus, molecular layer, hippocampal-amygdaloid transition area, and fimbria) were obtained using FreeSurfer 7. Subfield volumes were measured separately from head and body subregions. We fit linear mixed-effects models using log-transformed whole hippocampal/subregion/subfield volumes as dependent variables; age, sex, total intracranial volume, hemisphere and a group-by-hemisphere interaction as fixed effects; and subregion/subfield nested within hemisphere as a random effect. Significant results (P < 0.05) are hereby reported. At the whole hippocampal level, the dominant (predominantly involved) hemisphere of both variants showed 23-27% smaller volumes than controls. The non-dominant (less involved) hemisphere of the right-predominant variant also showed volume loss versus controls and the left-predominant variant. At the subregional level, both variants showed 17-28% smaller dominant hemisphere head, body, and tail than controls, with the right-predominant variant also showing 8-12% smaller non-dominant hemisphere head than controls and left-predominant variant. At the subfield level, the left-predominant variant showed 12-36% smaller volumes across all dominant hemisphere subfields and 14-15% smaller non-dominant hemisphere parasubiculum, presubiculum (head and body), subiculum (head) and hippocampal-amygdaloid transition area than controls. The right-predominant variant showed 16-49% smaller volumes across all dominant hemisphere subfields and 14-22% smaller parasubiculum, presubiculum, subiculum, cornu ammonis 3, hippocampal-amygdaloid transition area (all from the head) and fimbria of non-dominant hemisphere versus controls. Comparison of dominant hemispheres showed 16-29% smaller volumes of the parasubiculum, presubiculum (head) and fimbria in the right-predominant than left-predominant variant; comparison of non-dominant hemispheres showed 12-15% smaller cornu ammonis 3, cornu ammonis 4, dentate gyrus, hippocampal-amygdaloid transition area (all from the head) and cornu ammonis 1, cornu ammonis 3 and cornu ammonis 4 (all from the body) in the right-predominant variant. All hippocampal subregion/subfield volumes are affected in semantic dementia, although some are more affected in both dominant and non-dominant hemispheres of the right-predominant than the left-predominant variant by the time of presentation. Involvement of hippocampal structures is apparently more subregion dependent than subfield dependent, indicating possible superiority of subregion volumes as disease biomarkers.

Dataset Information

Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.

Publications

Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets