Ontology highlight
ABSTRACT:
SUBMITTER: McCann JJ
PROVIDER: S-EPMC3116789 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
McCann James J JJ Zheng Liqiang L Chiantia Salvatore S Bowen Mark E ME
Structure (London, England : 1993) 20110601 6
Tandem PDZ domains have been suggested to form structurally independent supramodules. However, dissimilarity between crystallography and NMR models emphasize their malleable conformation. Studies in full-length scaffold proteins are needed to examine the effect of tertiary interactions within their native context. Using single-molecule fluorescence to characterize the N-terminal PDZ tandem in PSD-95, we provide the first direct evidence that PDZ tandems can be structurally independent within a f ...[more]