Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC3117037 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hu Xinli X Atzler Dorothee D Xu Xin X Zhang Ping P Guo Haipeng H Lu Zhongbing Z Fassett John J Schwedhelm Edzard E Böger Rainer H RH Bache Robert J RJ Chen Yingjie Y
Arteriosclerosis, thrombosis, and vascular biology 20110414 7
<h4>Objective</h4>The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA).<h4>Methods and results</h4>We generated a global-DDAH1 gene-deficient (DDAH1(-/-)) mouse strain to examine the role of DDAH1 in ADMA and l-NMMA degradation and the physiological consequences of loss of DDAH1. Plasma and tissue ADMA and L ...[more]