Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC3117272 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Wang Huajin H Zhang Jing J Qiu Wei W Han Gil-Soo GS Carman George M GM Adeli Khosrow K
FEBS letters 20110520 12
Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1β, are localized at different subcellular compartments. A third splicing isoform, lipin-1γ was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1γ is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional expre ...[more]