Dataset Information

A conditional random fields method for RNA sequence-structure relationship modeling and conformation sampling.

ABSTRACT: Accurate tertiary structures are very important for the functional study of non-coding RNA molecules. However, predicting RNA tertiary structures is extremely challenging, because of a large conformation space to be explored and lack of an accurate scoring function differentiating the native structure from decoys. The fragment-based conformation sampling method (e.g. FARNA) bears shortcomings that the limited size of a fragment library makes it infeasible to represent all possible conformations well. A recent dynamic Bayesian network method, BARNACLE, overcomes the issue of fragment assembly. In addition, neither of these methods makes use of sequence information in sampling conformations. Here, we present a new probabilistic graphical model, conditional random fields (CRFs), to model RNA sequence-structure relationship, which enables us to accurately estimate the probability of an RNA conformation from sequence. Coupled with a novel tree-guided sampling scheme, our CRF model is then applied to RNA conformation sampling. Experimental results show that our CRF method can model RNA sequence-structure relationship well and sequence information is important for conformation sampling. Our method, named as TreeFolder, generates a much higher percentage of native-like decoys than FARNA and BARNACLE, although we use the same simple energy function as BARNACLE.zywang@ttic.edu; j3xu@ttic.eduSupplementary data are available at Bioinformatics online.

SUBMITTER: Wang Z

PROVIDER: S-EPMC3117333 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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A conditional random fields method for RNA sequence-structure relationship modeling and conformation sampling.

Wang Zhiyong Z Xu Jinbo J

Bioinformatics (Oxford, England) 20110701 13

<h4>Unlabelled</h4>Accurate tertiary structures are very important for the functional study of non-coding RNA molecules. However, predicting RNA tertiary structures is extremely challenging, because of a large conformation space to be explored and lack of an accurate scoring function differentiating the native structure from decoys. The fragment-based conformation sampling method (e.g. FARNA) bears shortcomings that the limited size of a fragment library makes it infeasible to represent all poss ...[more]

PMID: 21685058

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Dataset Information

A conditional random fields method for RNA sequence-structure relationship modeling and conformation sampling.

Publications

A conditional random fields method for RNA sequence-structure relationship modeling and conformation sampling.

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