Ontology highlight
ABSTRACT:
SUBMITTER: Petty TJ
PROVIDER: S-EPMC3117648 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Petty Tom J TJ Emamzadah Soheila S Costantino Lorenzo L Petkova Irina I Stavridi Elena S ES Saven Jeffery G JG Vauthey Eric E Halazonetis Thanos D TD
The EMBO journal 20110426 11
The p53 tumour suppressor gene, the most frequently mutated gene in human cancer, encodes a transcription factor that contains sequence-specific DNA binding and homo-tetramerization domains. Interestingly, the affinities of p53 for specific and non-specific DNA sites differ by only one order of magnitude, making it hard to understand how this protein recognizes its specific DNA targets in vivo. We describe here the structure of a p53 polypeptide containing both the DNA binding and oligomerizatio ...[more]