Ontology highlight
ABSTRACT:
SUBMITTER: Cardoso J
PROVIDER: S-EPMC3117861 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Cardoso Josiane J Lima Carla De Paula Cde P Leal Tiago T Gradia Daniela F DF Fragoso Stênio P SP Goldenberg Samuel S De Sá Renata Guerra RG Krieger Marco A MA
PloS one 20110617 6
Proteasomes are large protein complexes, whose main function is to degrade unnecessary or damaged proteins. The inhibition of proteasome activity in Trypanosoma cruzi blocks parasite replication and cellular differentiation. We demonstrate that proteasome-dependent proteolysis occurs during the cellular differentiation of T. cruzi from replicative non-infectious epimastigotes to non-replicative and infectious trypomastigotes (metacyclogenesis). No peaks of ubiquitin-mediated degradation were obs ...[more]