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Novel nanohybrids of silver particles on clay platelets for inhibiting silver-resistant bacteria.


ABSTRACT: We develop a novel nanohybrid showing a strong antibacterial activity on all of the tested pathogens, including methicillin-resistant Staphylococcus auerus and silver-resistant E. coli. The nanohybrid consists of silver nanoparticles (AgNPs) supported on 1 nm-thick silicate platelets (NSPs). The AgNP/NSP nanohybrid enables to encapsulate bacteria and triggers death signals from the cell membrane. The geographic shape of the NSPs concentrates AgNPs but impedes their penetration into attached cells, mitigating the detrimental effect of silver ion deposition in applied tissues. Moreover, the tightly tethered AgNPs on NSP surface achieve a stronger biocidal effect than silver nitrate, but bypassing Ag(+) mechanism, on silver-resistant bacteria. This nanohybrid presents an effective and safe antimicrobial agent in a new perspective.

SUBMITTER: Su HL 

PROVIDER: S-EPMC3117870 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Novel nanohybrids of silver particles on clay platelets for inhibiting silver-resistant bacteria.

Su Hong-Lin HL   Lin Siou-Hong SH   Wei Jiun-Chiou JC   Pao I-Chuan IC   Chiao Shu-Her SH   Huang Chieh-Chen CC   Lin Shinn-Zong SZ   Lin Jiang-Jen JJ  

PloS one 20110617 6


We develop a novel nanohybrid showing a strong antibacterial activity on all of the tested pathogens, including methicillin-resistant Staphylococcus auerus and silver-resistant E. coli. The nanohybrid consists of silver nanoparticles (AgNPs) supported on 1 nm-thick silicate platelets (NSPs). The AgNP/NSP nanohybrid enables to encapsulate bacteria and triggers death signals from the cell membrane. The geographic shape of the NSPs concentrates AgNPs but impedes their penetration into attached cell  ...[more]

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