Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens.
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ABSTRACT:
SUBMITTER: Brayton KA
PROVIDER: S-EPMC31191 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
Publications
Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens.
Brayton K A KA Knowles D P DP McGuire T C TC Palmer G H GH
Proceedings of the National Academy of Sciences of the United States of America 20010301 7
Ehrlichiae are responsible for important tick-transmitted diseases, including anaplasmosis, the most prevalent tick-borne infection of livestock worldwide, and the emerging human diseases monocytic and granulocytic ehrlichiosis. Antigenic variation of major surface proteins is a key feature of these pathogens that allows persistence in the mammalian host, a requisite for subsequent tick transmission. In Anaplasma marginale pseudogenes for two antigenically variable gene families, msp2 and msp3, ...[more]
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