Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
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ABSTRACT:
SUBMITTER: Balasubramanian S
PROVIDER: S-EPMC3119469 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian Shankar S Hurley Laurence H LH Neidle Stephen S
Nature reviews. Drug discovery 20110401 4
G-quadruplexes are four-stranded DNA structures that are over-represented in gene promoter regions and are viewed as emerging therapeutic targets in oncology, as transcriptional repression of oncogenes through stabilization of these structures could be a novel anticancer strategy. Many gene promoter G-quadruplexes have physicochemical properties and structural characteristics that might make them druggable, and their structural diversity suggests that a high degree of selectivity might be possib ...[more]
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