Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis.
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ABSTRACT:
SUBMITTER: Tengood JE
PROVIDER: S-EPMC3120092 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis.
Tengood Jillian E JE Ridenour Ryan R Brodsky Ross R Russell Alan J AJ Little Steven R SR
Tissue engineering. Part A 20110117 9-10
An externally regulated delivery model that permits temporal separation of multiple angiogenic factors was used for the delivery of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF). While bFGF plays a significant role in the sprouting of new capillaries, PDGF plays a role in the recruitment of mural cells, which stabilize neovessels. However, these two factors have been shown to inhibit each other, when presented together. Using the externally regulated model, sequ ...[more]
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