Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China.
Ontology highlight
ABSTRACT: Objective
To determine the relationship between selected cytokines and diabetes in Chinese subjects.Research design and methods
Adult patients with recent-onset type 1 diabetes (n=53), latent autoimmune diabetes in adults (LADA) (n=250), and type 2 diabetes (n=285) from multiple centers were compared with normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponectin.Results
After adjustment for age, sex, and BMI, all diabetes types had increased IL-6 and LCN2 (P<0.01), and all four cytokines were increased in LADA (P<0.01). In type 1 diabetes, adiponectin but not hs-CRP was increased (P<0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P<0.01). Adiponectin was correlated positively with GADA titer and negatively with hs-CRP (P<0.01 for both).Conclusions
In China, inflammatory markers are increased in all three major types of diabetes, but probably for different reasons, even in autoimmune diabetes.
SUBMITTER: Xiang Y
PROVIDER: S-EPMC3120206 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China.
Xiang Yufei Y Zhou Pengcheng P Li Xiaojue X Huang Gan G Liu Zhenqi Z Xu Aimin A Leslie R David RD Zhou Zhiguang Z
Diabetes care 20110526 7
<h4>Objective</h4>To determine the relationship between selected cytokines and diabetes in Chinese subjects.<h4>Research design and methods</h4>Adult patients with recent-onset type 1 diabetes (n=53), latent autoimmune diabetes in adults (LADA) (n=250), and type 2 diabetes (n=285) from multiple centers were compared with normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponecti ...[more]
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