Unknown

Dataset Information

0

Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China.


ABSTRACT:

Objective

To determine the relationship between selected cytokines and diabetes in Chinese subjects.

Research design and methods

Adult patients with recent-onset type 1 diabetes (n=53), latent autoimmune diabetes in adults (LADA) (n=250), and type 2 diabetes (n=285) from multiple centers were compared with normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponectin.

Results

After adjustment for age, sex, and BMI, all diabetes types had increased IL-6 and LCN2 (P<0.01), and all four cytokines were increased in LADA (P<0.01). In type 1 diabetes, adiponectin but not hs-CRP was increased (P<0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P<0.01). Adiponectin was correlated positively with GADA titer and negatively with hs-CRP (P<0.01 for both).

Conclusions

In China, inflammatory markers are increased in all three major types of diabetes, but probably for different reasons, even in autoimmune diabetes.

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC3120206 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China.

Xiang Yufei Y   Zhou Pengcheng P   Li Xiaojue X   Huang Gan G   Liu Zhenqi Z   Xu Aimin A   Leslie R David RD   Zhou Zhiguang Z  

Diabetes care 20110526 7


<h4>Objective</h4>To determine the relationship between selected cytokines and diabetes in Chinese subjects.<h4>Research design and methods</h4>Adult patients with recent-onset type 1 diabetes (n=53), latent autoimmune diabetes in adults (LADA) (n=250), and type 2 diabetes (n=285) from multiple centers were compared with normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponecti  ...[more]

Similar Datasets

| S-EPMC4395404 | biostudies-literature
| S-EPMC6284865 | biostudies-other
| S-EPMC7194964 | biostudies-literature
| S-EPMC8654203 | biostudies-literature
| S-EPMC6145925 | biostudies-literature
| S-EPMC2564527 | biostudies-literature
| S-EPMC2878316 | biostudies-literature
| S-EPMC8486042 | biostudies-literature
| S-EPMC5712192 | biostudies-literature
| S-EPMC8474566 | biostudies-literature