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12-Anilinomethyl-9?-hy-droxy-4,8-dimethyl-3,14-dioxatricyclo-[9.3.0.0]tetra-dec-7-en-13-one.

ABSTRACT: The title compound, C(21)H(27)NO(4), was synthesized from 9?-hy-droxy-parthenolide, which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The asymmetric unit contains two independent mol-ecules. In each, the ten-membered ring displays an approximative chair-chair conformation. Each of the five-membered rings adopts a flattened envelope conformation, the C(H)-C-C(H) atoms representing the flap lie out of the mean plane through the remaining four atoms by 0.443?(2) and 0.553?(2)?Å. The dihedral angle between the least-squares planes through the ten- and five-membered rings in the two mol-ecules are similar [22.54?(17) and 23.39?(14)°]. In the crystal, mol-ecules are linked by O-H?O, O-H?N and N-H?O hydrogen bonds.

SUBMITTER: Moumou M

PROVIDER: S-EPMC3120288 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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12-Anilinomethyl-9α-hy-droxy-4,8-dimethyl-3,14-dioxatricyclo-[9.3.0.0]tetra-dec-7-en-13-one.

Moumou Mohamed M Benharref Ahmed A Berraho Moha M Avignant Daniel D Oudahmane Abdelghani A Akssira Mohamed M

Acta crystallographica. Section E, Structure reports online 20110511 Pt 6

The title compound, C(21)H(27)NO(4), was synthesized from 9α-hy-droxy-parthenolide, which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The asymmetric unit contains two independent mol-ecules. In each, the ten-membered ring displays an approximative chair-chair conformation. Each of the five-membered rings adopts a flattened envelope conformation, the C(H)-C-C(H) atoms representing the flap lie out of the mean plane through the remaining four atoms by 0.443 ( ...[more]

PMID: 21754777

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