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2-{(1R,2R)-2-[Bis(4-methyl-benz-yl)amino]-cyclo-hex-yl}isoindoline-1,3-dione.

ABSTRACT: In the title mol-ecule, C(30)H(32)N(2)O(2), the two tolyl rings form dihedral angles of 65.8?(1) and 6.6?(1)° with the isoindole-1,3-dione mean plane. The cyclo-hexane ring adopts a chair conformation.

SUBMITTER: Li C

PROVIDER: S-EPMC3120613 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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2-{(1R,2R)-2-[Bis(4-methyl-benz-yl)amino]-cyclo-hex-yl}isoindoline-1,3-dione.

Li Chao C Fu Xiang-Kai XK Wu Chuan-Long CL Huang Jing J

Acta crystallographica. Section E, Structure reports online 20110520 Pt 6

In the title mol-ecule, C(30)H(32)N(2)O(2), the two tolyl rings form dihedral angles of 65.8 (1) and 6.6 (1)° with the isoindole-1,3-dione mean plane. The cyclo-hexane ring adopts a chair conformation. ...[more]

PMID: 21754852

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Crystal structures of 2-[3,5-bis-(bromo-meth-yl)-2,4,6-tri-ethyl-benz-yl]isoindoline-1,3-dione and 2-{5-(bromo-meth-yl)-3-[(1,3-dioxoisoindolin-2-yl)meth-yl]-2,4,6-tri-ethyl-benz-yl}isoindoline-1,3-dione.

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Crystal structure of 2,2'-({[2-(trityl-sulfan-yl)benz-yl]azane-diyl}bis-(ethane-2,1-di-yl))bis-(isoindoline-1,3-dione).

Project description:In the structure of the title compound, C46H37N3O4S, the planes of the two isoindoline units make a dihedral angle of 77.86 (3)°. The dihedral angles between the benzyl plane and the isoindoline units are 79.56 (4) and 3.74 (9)°. The geometry at the S atom shows a short [1.7748 (17) Å] S-Cbenz-yl and a long [1.8820 (15) Å] S-Ctrit-yl bond and the C-S-C angle is 108.40 (7)°. N-C bond lengths around the azane N atom are in the range 1.454 (2)-1.463 (2) Å. he crystal packing exhibts two rather 'non-classical' C-H⋯O hydrogen bonds that result in stacking of the molecules along the a as well as the b axis and give rise to columnar sub-structures.

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2-(2-Fluoro-4-hy-droxy-benz-yl)isoindoline-1,3-dione.

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2-[4-tert-Butyl-5-(2-chloro-benz-yl)-1,3-thia-zol-2-yl]isoindoline-1,3-dione.

Project description:In the title compound, C(22)H(19)ClN(2)O(2)S, the dihedral angle between the phenyl-ene ring and the phthalimide ring system is 4.4?(1)°. There is no hydrogen bonding or ?-? stacking in the crystal structure.

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2-{(1S*,2S*)-2-[(E)-(2,4-Dihy-droxy-benzyl-idene)amino]-cyclo-hex-yl}isoindoline-1,3-dione.

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2-(3-Bromo-prop-yl)isoindoline-1,3-dione.

Project description:In the title compound, C(11)H(10)BrNO(2), the dihedral angle between the five- and six-membered rings of the phthalamide system is 1.00?(16)°. There are no significant inter-molecular inter-ations except for van der Waals contacts.

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2-(2-Bromo-eth-yl)isoindoline-1,3-dione.

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2-[2-(Methyl-sulfon-yl)eth-yl]isoindoline-1,3-dione.

Project description:In the mol-ecule of the title compound, C(11)H(11)NO(4)S, the isoindoline ring system is almost planar with a maximum deviation of 0.008?(3)Å. In the crystal structure, inter-molecular C-H?O inter-actions link the mol-ecules into a three-dimensional network. ?-? contacts between the isoindoline rings [centroid-centroid distances = 3.592?(1) and 3.727?(1)?Å] may further stabilize the structure.

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2-[2-(Trimethyl-silyl)eth-yl]isoindoline-1,3-dione.

Project description:In the course of our studies of silicon-containing anti-cancer compounds, the title compound, C(13)H(17)NO(2)Si, was synthesized. The geometrical parameters including the geometry about the Si atom are typical. The mol-ecules form dimers via a weak C-H?O inter-action described by the graph set R(2) (2)(10). The dimers are assembled in rows stacked in the crystallographic b-axis direction via ?-? inter-actions with a 3.332?(3)?Å separation between the rows.

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2-[(3S)-5-Oxooxolan-3-yl]isoindoline-1,3-dione.

Project description:The oxolan-2-one ring in the title compound, C(12)H(9)NO(4), has an envelope conformation with the atom linking the two five-membered rings being the flap atom.

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