Ontology highlight
ABSTRACT:
SUBMITTER: Glotzbach JP
PROVIDER: S-EPMC3120839 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Glotzbach Jason P JP Januszyk Michael M Vial Ivan N IN Wong Victor W VW Gelbard Alexander A Kalisky Tomer T Thangarajah Hariharan H Longaker Michael T MT Quake Stephen R SR Chu Gilbert G Gurtner Geoffrey C GC
PloS one 20110622 6
An incomplete understanding of the nature of heterogeneity within stem cell populations remains a major impediment to the development of clinically effective cell-based therapies. Transcriptional events within a single cell are inherently stochastic and can produce tremendous variability, even among genetically identical cells. It remains unclear how mammalian cellular systems overcome this intrinsic noisiness of gene expression to produce consequential variations in function, and what impact th ...[more]