Ontology highlight
ABSTRACT:
SUBMITTER: Allen BL
PROVIDER: S-EPMC3121104 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Allen Benjamin L BL Song Jane Y JY Izzi Luisa L Althaus Irene W IW Kang Jong-Sun JS Charron Frédéric F Krauss Robert S RS McMahon Andrew P AP
Developmental cell 20110601 6
Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1). However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1, CDO, and BOC, as putative coreceptors for HH ligands. A central question is to what degree these coreceptors function similarly and what their collective requirement in HH signal transduction is. Here we provide evidence that GAS1, CDO, and BOC play overlapping and essential roles during HH-mediated ventral neural patter ...[more]