Tango between ubiquitin ligase and deubiquitinase keeps cyclin A tag free.
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ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC3121174 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Tango between ubiquitin ligase and deubiquitinase keeps cyclin A tag free.
Molecular cell 20110501 4
Ubiquitin ligases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose each other during ubiquitination. In this issue of Molecular Cell, Huang et al. (2011) provide a counterintuitive example of a USP residing in an E3 complex, and establish Usp37 as a gatekeeper of APC/C-mediated ubiquitination of cyclin A. ...[more]
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