Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.
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ABSTRACT:
SUBMITTER: Murata T
PROVIDER: S-EPMC3121345 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.
Murata Takayuki T Noda Chieko C Saito Shinichi S Kawashima Daisuke D Sugimoto Atsuko A Isomura Hiroki H Kanda Teru T Yokoyama Kazunari K KK Tsurumi Tatsuya T
The Journal of biological chemistry 20110427 25
Reactivation of the Epstein-Barr virus from latency is dependent on expression of the BZLF1 viral immediate-early protein. The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical inducers such as 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore. We found that Jun dimerization protein 2 (JDP2) plays a significant role in suppressing Zp activity. Reporter, EMSA, and ChIP assays of a Zp mutant virus revealed JDP2 association with Zp at th ...[more]
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