Ontology highlight
ABSTRACT:
SUBMITTER: Sy SM
PROVIDER: S-EPMC3121383 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Sy Shirley M-H SM Jiang Jun J Dong Sui-sui SS Lok Gabriel Tsz Mei GT Wu Jun J Cai Hua H Yeung Enoch S L ES Huang Jun J Chen Junjie J Deng Yiqun Y Huen Michael S Y MS
The Journal of biological chemistry 20110510 25
Histone ubiquitylation is emerging as an important protective component in cellular responses to DNA damage. The ubiquitin ligases RNF8 and RNF168 assemble ubiquitin chains onto histone molecules surrounding DNA breaks and facilitate retention of DNA repair proteins. Although RNF8 and RNF168 play important roles in repair of DNA double strand breaks, their requirement for cell protection from replication stress is largely unknown. In this study, we uncovered RNF168-independent roles of RNF8 in r ...[more]