Ontology highlight
ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC3121544 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Gao Jianjun J Xu Hong H Weinberg Clarice C Huang Xuemei X Park Yikyung Y Hollenbeck Albert A Blair Aaron A Schatzkin Arthur A Burch Lauranell L Chen Honglei H
Neuro-degenerative diseases 20110113 5
<h4>Background</h4>Smokers have a lower risk of Parkinson's disease (PD). Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Investigations into these SNPs may help explain the nature and mechanisms of the smoking-PD relationship.<h4>Objective</h4>To examine whether the genetic variations that were consistently associated with s ...[more]