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Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings.


ABSTRACT: Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.

SUBMITTER: Enlow EM 

PROVIDER: S-EPMC3122105 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings.

Enlow Elizabeth M EM   Luft J Christopher JC   Napier Mary E ME   DeSimone Joseph M JM  

Nano letters 20110125 2


Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings  ...[more]

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