Ontology highlight
ABSTRACT:
SUBMITTER: Enlow EM
PROVIDER: S-EPMC3122105 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Enlow Elizabeth M EM Luft J Christopher JC Napier Mary E ME DeSimone Joseph M JM
Nano letters 20110125 2
Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings ...[more]