Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto R
PROVIDER: S-EPMC3122205 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Yamamoto Rie R Akazawa Hiroshi H Fujihara Hiroaki H Ozasa Yukako Y Yasuda Noritaka N Ito Kaoru K Kudo Yoko Y Qin Yingjie Y Ueta Yoichi Y Komuro Issei I
The Journal of biological chemistry 20110427 24
The activation of renin-angiotensin system contributes to the development of metabolic syndrome and diabetes as well as hypertension. However, it remains undetermined how renin-angiotensin system is implicated in feeding behavior. Here, we show that angiotensin II type 1 (AT(1)) receptor signaling regulates the hypothalamic neurocircuit that is involved in the control of food intake. Compared with wild-type Agtr1a(+/+) mice, AT(1) receptor knock-out (Agtr1a(-/-)) mice were hyperphagic and obese ...[more]