Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3122209 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Li Hui H Solomon Emilia E Duhachek Muggy Sara S Sun Danqiong D Zolkiewska Anna A
The Journal of biological chemistry 20110425 24
Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutated in breast cancer. We report here that ADAM12 expression in cultured mammalian cells is up-regulated by Notch signals. Expression of a constitutively active form of Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by co-culture with ligand-expressing cells increases ADAM12 protein and mRNA levels. Up-regulation of ADAM12 expression by Notch requires new tr ...[more]