Ontology highlight
ABSTRACT:
SUBMITTER: Iwasa H
PROVIDER: S-EPMC3122234 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Iwasa Hisanori H Meshitsuka Shunsuke S Hongo Kunihiro K Mizobata Tomohiro T Kawata Yasushi Y
The Journal of biological chemistry 20110420 24
Co-chaperonin GroES from Escherichia coli works with chaperonin GroEL to mediate the folding reactions of various proteins. However, under specific conditions, i.e. the completely disordered state in guanidine hydrochloride, this molecular chaperone forms amyloid fibrils similar to those observed in various neurodegenerative diseases. Thus, this is a good model system to understand the amyloid fibril formation mechanism of intrinsically disordered proteins. Here, we identified a critical interme ...[more]