Ontology highlight
ABSTRACT:
SUBMITTER: Flanagan JM
PROVIDER: S-EPMC3123027 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Flanagan Jonathan M JM Frohlich Denise M DM Howard Thad A TA Schultz William H WH Driscoll Catherine C Nagasubramanian Ramamoorthy R Mortier Nicole A NA Kimble Amy C AC Aygun Banu B Adams Robert J RJ Helms Ronald W RW Ware Russell E RE
Blood 20110422 24
Stroke is a devastating complication of sickle cell anemia (SCA), affecting 5% to 10% of patients before adulthood. Several candidate genetic polymorphisms have been proposed to affect stroke risk, but few have been validated, mainly because previous studies were hampered by relatively small sample sizes and the absence of additional patient cohorts for validation testing. To verify the accuracy of proposed genetic modifiers influencing stroke risk in SCA, we performed genotyping for 38 publishe ...[more]