Ontology highlight
ABSTRACT:
SUBMITTER: Zotti T
PROVIDER: S-EPMC3123060 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Zotti Tiziana T Uva Antonio A Ferravante Angela A Vessichelli Mariangela M Scudiero Ivan I Ceccarelli Michele M Vito Pasquale P Stilo Romania R
The Journal of biological chemistry 20110425 26
Tumor necrosis factor receptor-associated factor (TRAF) proteins are cytoplasmic regulatory molecules that function as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this study, we show that TRAF7, the unique noncanonical member of the TRAF family, physically associates with IκB kinase/NF-κB essential modulator (NEMO) and with the RelA/p65 (p65) member of the NF-κB transcription factor family. TRAF7 promotes Lys-29-linked polyubiquitination of ...[more]