Ontology highlight
ABSTRACT:
SUBMITTER: Newton GL
PROVIDER: S-EPMC3123436 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Newton Gerald L GL Buchmeier Nancy N La Clair James J JJ Fahey Robert C RC
Bioorganic & medicinal chemistry 20110524 13
The mycothiol biosynthesis enzyme MshC catalyzes the ligation of cysteine with the pseudodisaccharide GlcN-Ins and has been identified as an essential enzyme in Mycobacterium tuberculosis. We now report on the development of NTF1836 as a micromolar inhibitor of MshC. Using commercial libraries, we conducted preliminary structure-activity relationship (SAR) studies on NTF1836. Based on this data, NTF1836 and five structurally related compounds showed similar activity towards clinical strains of M ...[more]