Ontology highlight
ABSTRACT:
SUBMITTER: Vaira V
PROVIDER: S-EPMC3124121 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Vaira Valentina V Faversani Alice A Dohi Takehiko T Maggioni Marco M Nosotti Mario M Tosi Delfina D Altieri Dario C DC Bosari Silvano S
The American journal of pathology 20110506 6
Human Scribble (Scrib) is an evolutionary-conserved cell polarity protein, but its potential role in human cancer is controversial. Herein, we show that Scrib is nearly universally overexpressed in cultured tumor cell lines and genetically disparate cancer patient series compared with matched normal tissues in vivo. Instead of a membrane association seen in normal epithelia, tumor-associated Scrib is mislocalized and found predominantly in the cytosol. Small-interfering RNA silencing of Scrib in ...[more]