Ontology highlight
ABSTRACT:
SUBMITTER: Bunin GR
PROVIDER: S-EPMC3124307 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Bunin Greta R GR Felice Marc A MA Davidson William W Friedman Debra L DL Shields Carol L CL Maidment Andrew A O'Shea Michael M Nichols Kim E KE Leahey Ann A Dunkel Ira J IJ Jubran Rima R Rodriguez-Galindo Carlos C Schmidt Mary Lou ML Weinstein Joanna L JL Goldman Stewart S Abramson David H DH Wilson Matthew W MW Gallie Brenda L BL Chan Helen S L HS Shapiro Michael M Cnaan Avital A Ganguly Arupa A Meadows Anna T AT
International journal of cancer 20110501 10
Although ionizing radiation induces germline mutations in animals, human studies of radiation-exposed populations have not detected an effect. We conducted a case-control study of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation, to investigate gonadal radiation exposure of parents from medical sources before their child's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; fathers of 184 cases and 223 friend and ...[more]