Ontology highlight
ABSTRACT:
SUBMITTER: Older Aguilar AM
PROVIDER: S-EPMC3124317 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Older Aguilar Anastazia M AM Guethlein Lisbeth A LA Adams Erin J EJ Abi-Rached Laurent L Moesta Achim K AK Parham Peter P
Journal of immunology (Baltimore, Md. : 1950) 20100830 7
Interactions between HLA class I and killer cell Ig-like receptors (KIRs) diversify human NK cell responses. Dominant KIR ligands are the C1 and C2 epitopes of MHC-C, a young locus restricted to humans and great apes. C1- and C1-specific KIRs evolved first, being present in orangutan and functionally like their human counterparts. Orangutans lack C2 and C2-specific KIRs, but have a unique C1+C2-specific KIR that binds equally to C1 and C2. A receptor with this specificity likely provided the mec ...[more]