Ontology highlight
ABSTRACT:
SUBMITTER: Jurd R
PROVIDER: S-EPMC3124443 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20071025 1
The N-methyl-D-aspartate receptor (NMDAR) plays a critical role in synaptic plasticity. Post-translational modifications of NMDARs, such as phosphorylation, alter both the activity and trafficking properties of NMDARs. Ubiquitination is increasingly being recognized as another post-translational modification that can alter synaptic protein composition and function. We identified Mind bomb-2 as an E3 ubiquitin ligase that interacts with and ubiquitinates the NR2B subunit of the NMDAR in mammalian ...[more]