LipA, a tyrosine and lipid phosphatase involved in the virulence of Listeria monocytogenes.

ABSTRACT: Intracellular bacterial pathogens manipulate host cell functions by producing enzymes that stimulate or antagonize signal transduction. The Listeria monocytogenes genome contains a gene, lmo1800, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that the lmo1800-encoded protein LipA is secreted by Listeria and displays tyrosine as well as lipid phosphatase activity in vitro. Bacteria lacking LipA are severely attenuated in virulence in vivo, thus revealing a so-far-undescribed enzymatic activity involved in Listeria infection.

SUBMITTER: Kastner R 

PROVIDER: S-EPMC3125854 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature