Cytomegalovirus UL103 controls virion and dense body egress.
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ABSTRACT:
SUBMITTER: Ahlqvist J
PROVIDER: S-EPMC3126192 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Cytomegalovirus UL103 controls virion and dense body egress.
Ahlqvist Jenny J Mocarski Edward E
Journal of virology 20110223 10
Human cytomegalovirus UL103 encodes a tegument protein that is conserved across herpesvirus subgroups. Mutant viruses lacking this gene product exhibit dramatically reduced accumulation of cell-free virus progeny and poor cell-to-cell spread. Given that viral proteins and viral DNA accumulate with normal kinetics in cells infected with mutant virus, UL103 appears to function during the late phase of replication, playing a critical role in egress of capsidless dense bodies and virions. Few dense ...[more]
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