Ontology highlight
ABSTRACT:
SUBMITTER: Engel S
PROVIDER: S-EPMC3126231 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Engel Sabrina S Heger Thomas T Mancini Roberta R Herzog Fabian F Kartenbeck Jürgen J Hayer Arnold A Helenius Ari A
Journal of virology 20110223 9
After binding to its cell surface receptor ganglioside GM1, simian virus 40 (SV40) is endocytosed by lipid raft-mediated endocytosis and slowly transported to the endoplasmic reticulum, where partial uncoating occurs. We analyzed the intracellular pathway taken by the virus in HeLa and CV-1 cells by using a targeted small interfering RNA (siRNA) silencing screen, electron microscopy, and live-cell imaging as well as by testing a variety of cellular inhibitors and other perturbants. We found that ...[more]