Mobility and interactions of coronavirus nonstructural protein 4.
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ABSTRACT:
SUBMITTER: Hagemeijer MC
PROVIDER: S-EPMC3126240 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Mobility and interactions of coronavirus nonstructural protein 4.
Hagemeijer Marne C MC Ulasli Mustafa M Vonk Annelotte M AM Reggiori Fulvio F Rottier Peter J M PJ de Haan Cornelis A M CA
Journal of virology 20110223 9
Green fluorescent protein (GFP)-tagged mouse hepatitis coronavirus nonstructural protein 4 (nsp4) was shown to localize to the endoplasmic reticulum (ER) and to be recruited to the coronavirus replicative structures. Fluorescence loss in photobleaching and fluorescence recovery after photobleaching experiments demonstrated that while the membranes of the ER are continuous with those harboring the replicative structures, the mobility of nsp4 at the latter structures is relatively restricted. In a ...[more]
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