Ontology highlight
ABSTRACT:
SUBMITTER: Qi DL
PROVIDER: S-EPMC3126332 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Qi Dong-Lai DL Ohhira Takahito T Fujisaki Chikako C Inoue Toshiaki T Ohta Tsutomu T Osaki Mitsuhiko M Ohshiro Eriko E Seko Tomomi T Aoki Shinsuke S Oshimura Mitsuo M Kugoh Hiroyuki H
Molecular and cellular biology 20110207 8
Telomerase, a ribonucleoprotein enzyme that maintains telomere length, is crucial for cellular immortalization and cancer progression. Telomerase activity is attributed primarily to the expression of telomerase reverse transcriptase (TERT). Using microcell-mediated chromosome transfer (MMCT) into the mouse melanoma cell line B16F10, we previously found that human chromosome 5 carries a gene, or genes, that can negatively regulate TERT expression (H. Kugoh, K. Shigenami, K. Funaki, J. Barrett, an ...[more]