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Loss of Werner syndrome protein function promotes aberrant mitotic recombination.

ABSTRACT: The chromosome 8p11-12 Werner syndrome (WRN ) locus encodes a RecQ helicase protein of unknown function that possesses both 3' --> 5' helicase and 3' --> 5' exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and generate few viable gene conversion-type recombinants. These findings indicate that WRN plays a role in mitotic recombination, and that a loss of WRN function may promote genetic instability and disease via recombination-initiated mitotic arrest, cell death, or gene rearrangement.

SUBMITTER: Prince PR

PROVIDER: S-EPMC312674 | biostudies-literature | 2001 Apr

REPOSITORIES: biostudies-literature

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Loss of Werner syndrome protein function promotes aberrant mitotic recombination.

Prince P R PR Emond M J MJ Monnat R J RJ

Genes & development 20010401 8

The chromosome 8p11-12 Werner syndrome (WRN ) locus encodes a RecQ helicase protein of unknown function that possesses both 3' --> 5' helicase and 3' --> 5' exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and generate few viable gene conversion-type recombinants. These findings indicate that WRN plays a role in mitotic recombination, and that a loss of WRN function may promote genetic instability and disease vi ...[more]

PMID: 11316787

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2024-01-26 | GSE248012 | GEO

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