The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor.
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ABSTRACT:
SUBMITTER: Prokhortchouk A
PROVIDER: S-EPMC312733 | biostudies-literature | 2001 Jul
REPOSITORIES: biostudies-literature
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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor.
Prokhortchouk A A Hendrich B B Jørgensen H H Ruzov A A Wilm M M Georgiev G G Bird A A Prokhortchouk E E
Genes & development 20010701 13
We describe a novel mammalian DNA binding activity that requires at least two symmetrically methylated CpG dinucleotides in its recognition sequence, preferably within the sequence 5'CGCG. A key component of the activity is Kaiso, a protein with POZ and zinc-finger domains that is known to associate with p120 catenin. We find that Kaiso behaves as a methylation-dependent transcriptional repressor in transient transfection assays. Kaiso is a constituent of one of two methyl-CpG binding complexes ...[more]
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