Ontology highlight
ABSTRACT:
SUBMITTER: Smith NJ
PROVIDER: S-EPMC3127537 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Smith Nicola J NJ Ward Richard J RJ Stoddart Leigh A LA Hudson Brian D BD Kostenis Evi E Ulven Trond T Morris Joanne C JC Tränkle Christian C Tikhonova Irina G IG Adams David R DR Milligan Graeme G
Molecular pharmacology 20110415 1
Allosteric agonists are powerful tools for exploring the pharmacology of closely related G protein-coupled receptors that have nonselective endogenous ligands, such as the short chain fatty acids at free fatty acid receptors 2 and 3 (FFA2/GPR43 and FFA3/GPR41, respectively). We explored the molecular mechanisms mediating the activity of 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide (4-CMTB), a recently described phenylacetamide allosteric agonist and allosteric modulator of endogenous ...[more]