Ontology highlight
ABSTRACT:
SUBMITTER: Kaci G
PROVIDER: S-EPMC3127691 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Kaci Ghalia G Lakhdari Omar O Doré Joël J Ehrlich S Dusko SD Renault Pierre P Blottière Hervé M HM Delorme Christine C
Applied and environmental microbiology 20110520 13
Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8). ...[more]