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Phylogenetic and functional analysis of Aspergillus fumigatus MGTC, a fungal protein homologous to a bacterial virulence factor.


ABSTRACT: MgtC is important for the survival of several bacterial pathogens in macrophages and for growth under magnesium limitation. Among eukaryotes, a gene homologous to mgtC was found only in the pathogenic fungus Aspergillus fumigatus. Our data show that the A. fumigatus MgtC (AfuMgtC) protein does not have the same function as the bacterial MgtC proteins.

SUBMITTER: Gastebois A 

PROVIDER: S-EPMC3127704 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Phylogenetic and functional analysis of Aspergillus fumigatus MGTC, a fungal protein homologous to a bacterial virulence factor.

Gastebois Amandine A   Blanc Potard Anne-Beatrice AB   Gribaldo Simonetta S   Beau Rémi R   Latgé Jean Paul JP   Mouyna Isabelle I  

Applied and environmental microbiology 20110520 13


MgtC is important for the survival of several bacterial pathogens in macrophages and for growth under magnesium limitation. Among eukaryotes, a gene homologous to mgtC was found only in the pathogenic fungus Aspergillus fumigatus. Our data show that the A. fumigatus MgtC (AfuMgtC) protein does not have the same function as the bacterial MgtC proteins. ...[more]

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