Ontology highlight
ABSTRACT:
SUBMITTER: Smith JJ
PROVIDER: S-EPMC3127888 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Smith Jennifer J JJ Hill Justine M JM Little Michelle J MJ Nicholson Graham M GM King Glenn F GF Alewood Paul F PF
Proceedings of the National Academy of Sciences of the United States of America 20110613 26
The three-disulfide inhibitor cystine knot (ICK) motif is a fold common to venom peptides from spiders, scorpions, and aquatic cone snails. Over a decade ago it was proposed that the ICK motif is an elaboration of an ancestral two-disulfide fold coined the disulfide-directed β-hairpin (DDH). Here we report the isolation, characterization, and structure of a novel toxin [U(1)-liotoxin-Lw1a (U(1)-LITX-Lw1a)] from the venom of the scorpion Liocheles waigiensis that is the first example of a native ...[more]