Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
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ABSTRACT:
SUBMITTER: Arking DE
PROVIDER: S-EPMC3128111 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
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Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
Arking Dan E DE Junttila M Juhani MJ Goyette Philippe P Huertas-Vazquez Adriana A Eijgelsheim Mark M Blom Marieke T MT Newton-Cheh Christopher C Reinier Kyndaron K Teodorescu Carmen C Uy-Evanado Audrey A Carter-Monroe Naima N Kaikkonen Kari S KS Kortelainen Marja-Leena ML Boucher Gabrielle G Lagacé Caroline C Moes Anna A Zhao XiaoQing X Kolodgie Frank F Rivadeneira Fernando F Hofman Albert A Witteman Jacqueline C M JC Uitterlinden André G AG Marsman Roos F RF Pazoki Raha R Bardai Abdennasser A Koster Rudolph W RW Dehghan Abbas A Hwang Shih-Jen SJ Bhatnagar Pallav P Post Wendy W Hilton Gina G Prineas Ronald J RJ Li Man M Köttgen Anna A Ehret Georg G Boerwinkle Eric E Coresh Josef J Kao W H Linda WH Psaty Bruce M BM Tomaselli Gordon F GF Sotoodehnia Nona N Siscovick David S DS Burke Greg L GL Marbán Eduardo E Spooner Peter M PM Cupples L Adrienne LA Jui Jonathan J Gunson Karen K Kesäniemi Y Antero YA Wilde Arthur A M AA Tardif Jean-Claude JC O'Donnell Christopher J CJ Bezzina Connie R CR Virmani Renu R Stricker Bruno H C H BH Tan Hanno L HL Albert Christine M CM Chakravarti Aravinda A Rioux John D JD Huikuri Heikki V HV Chugh Sumeet S SS
PLoS genetics 20110630 6
Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000-300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies, and identify ...[more]
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