Ontology highlight
ABSTRACT:
SUBMITTER: Bushey D
PROVIDER: S-EPMC3128387 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Bushey Daniel D Tononi Giulio G Cirelli Chiara C
Science (New York, N.Y.) 20110601 6037
The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary for synaptic renormalization. We found that, in three Drosophila neuronal circuits, synapse size or number increases after a few hours of wake and decreases only if flies are allowed to sleep. A richer wake experience resulted in both larger synaptic growth and gre ...[more]