Ontology highlight
ABSTRACT:
SUBMITTER: Liu DW
PROVIDER: S-EPMC3128613 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Liu Da-Wei DW Hsu Chia-Hao CH Tsai Su-Mei SM Hsiao Chung-Der CD Wang Wen-Pin WP
PloS one 20110701 7
Many organs in vertebrates are left-right asymmetrical located. For example, liver is at the right side and stomach is at the left side in human. Fibroblast growth factor (Fgf) signaling is important for left-right asymmetry. To investigate the roles of Fgfr2 signaling in zebrafish left-right asymmetry, we used splicing blocking morpholinos to specifically block the splicing of fgfr2b and fgfr2c variants, respectively. We found that the relative position of the liver and the pancreas were disrup ...[more]