Confounding effects in "A six-gene signature predicting breast cancer lung metastasis".
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ABSTRACT:
SUBMITTER: Culhane AC
PROVIDER: S-EPMC3128918 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Confounding effects in "A six-gene signature predicting breast cancer lung metastasis".
Culhane Aedín C AC Quackenbush John J
Cancer research 20090901 18
The majority of breast cancer deaths result from metastases rather than from direct effects of the primary tumor itself. Recently, Landemaine and colleagues described a six-gene signature purported to predict lung metastasis risk. They analyzed gene expression in 23 metastases from breast cancer patients (5 lung, 18 non-lung) identifying a 21-gene signature. Expression of 16 of these was analyzed in primary breast tumors from 72 patients with known outcome, and six were selected that were predic ...[more]
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