Ontology highlight
ABSTRACT:
SUBMITTER: Barclay AN
PROVIDER: S-EPMC3128989 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Current opinion in immunology 20090214 1
SIRPalpha is an inhibitory receptor present on myeloid cells that interacts with a widely distributed membrane protein CD47. The activating member SIRPbeta, despite extensive sequence similarity to SIRPalpha in the extracellular region, shows negligible binding to CD47. The SIRPalpha/CD47 interaction is unusual in that it can lead to bidirectional signalling through both SIRPalpha and CD47. This review concentrates on the interactions of SIRPalpha with CD47 where recent data have shed light on t ...[more]