Ontology highlight
ABSTRACT:
SUBMITTER: Islam S
PROVIDER: S-EPMC3129258 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Islam Saiful S Kjällquist Una U Moliner Annalena A Zajac Pawel P Fan Jian-Bing JB Lönnerberg Peter P Linnarsson Sten S
Genome research 20110504 7
Our understanding of the development and maintenance of tissues has been greatly aided by large-scale gene expression analysis. However, tissues are invariably complex, and expression analysis of a tissue confounds the true expression patterns of its constituent cell types. Here we describe a novel strategy to access such complex samples. Single-cell RNA-seq expression profiles were generated, and clustered to form a two-dimensional cell map onto which expression data were projected. The resulti ...[more]