Dataset Information

Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling.

ABSTRACT:

Background

Activated protein C (APC) is a vitamin K-dependent plasma serine protease that down-regulates clotting and inflammatory pathways. It is known that APC exerts a cardioprotective effect by decreasing apoptosis of cardiomyocytes and inhibiting expression of inflammatory mediators after myocardial ischemia.

Objectives

The objective of this study was to understand the mechanism of the APC-mediated cardioprotection against ischemic injury.

Methods

Cardioprotective activities of wild-type APC and two derivatives, having either dramatically reduced anticoagulant activity or lacking signaling activity, were monitored in an acute ischemia/reperfusion injury model in which the left anterior descending coronary artery (LAD) was occluded.